Towards polio eradication: Randomized control trial assessing OPV transmissibility in mexican communities

Polio eradication: the OPV paradox.

Routine and mass administration of oral polio vaccine (OPV) since 1961 has prevented many millions of cases of paralytic poliomyelitis. The public health value of this inexpensive and easily administered product has been extraordinary. Progress of the Global Polio Eradication Initiative has further defined the value of OPV as well as its risk through vaccine-associated paralytic poliomyelitis (...

Preventing Polio Post-eradication: Revertant Proportion Patterns of OPV Serotypes

Polio eradication.

The goal of polio eradication in the Western Pacific Region is within reach. The last case of polio seen in the region occurred in Cambodia in March 1997 and the region aims to be certified polio-free by the World Health Organization (WHO) in the year 2000. The Global Commission for Certification of Eradication of Poliomyelitis has specified three criteria to be fulfilled by countries in order ...

Polio eradication in India: pulse polio immunization.

The magnitude of the public health program for the eradication of poliomyelitis launched by the Government of India and the State Governments has few parallels. Over 87.77 million children, including 79.29 million children less than three years of age, were given a dose of oral polio on one day throughout the country on 9 December 1995. In the second round on 20 January 1996 over 93.118 million...

Assessing the stability of polio eradication after the withdrawal of oral polio vaccine

A fundamental complexity of polio eradication is that the elimination of wild poliovirus (WPV) alters the risk-benefit profile of using oral polio vaccine (OPV)—as WPV is eliminated, OPV produces an increasing proportion of the paralytic disease burden since, in rare instances, OPV causes paralysis in vaccine recipients and generates circulating vaccine-derived polio outbreaks (cVDPV) in under-...